Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols

Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols (Methods in Molecular Biology) by Peter Bross and Niels Gregersen English | 1st Edition | August 19, 2010 | ISBN-10: 1607617552 | 330 pages | PDF | 7 MB How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book’s coverage continues with detailed descriptions of protocols for relevant experimental approaches.

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